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Dr. Melanie Cree explains medical results to Noelani Schulmeister in a study using GLP-1 medication to treat PMOS Friday, July 10, 2026 in Aurora, Colo. (AP Photo/Brittany Peterson)

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GLP-1 medication used in the polyendocrine metabolic ovarian syndrome trial Friday, July 10, 2026 in Aurora, Colo. (AP Photo/Brittany Peterson)

Luigi Mangione’s guilty plea to federal stalking charges in the killing of UnitedHealthcare CEO Brian Thompson resolves one of two cases against him. He is set to go on trial for state murder charges on Sept. 8. Thompson was shot outside a New York City hotel on Dec. 4, 2024, while heading to an investor conference. Mangione was arrested five days later at a McDonald’s in Pennsylvania. The case has seen numerous legal twists, including the dismissal of terrorism charges and a judge taking the death penalty off the table. Mangione briefly planned a psychiatric defense but abandoned it. He pleaded guilty in the federal case on Friday.

Luigi Mangione is expected to plead guilty as early as Friday in the federal case accusing him of stalking and killing UnitedHealthcare CEO Brian Thompson, a stunning development in a case that rattled business leaders while galvanizing their critics, according to a person familiar with the matter. The person was not authorized to talk publicly about the case and spoke to The Associated Press on the condition of anonymity. The person cautioned that Mangione could change his mind. Mangione is accused of stalking Thompson, 50, then shooting him outside a New York City hotel on Dec. 4, 2024, as the executive walked to UnitedHealth Group’s annual investor conference. Mangione is due in court on Friday for a hastily scheduled hearing in the federal case. Mangione’s lawyers declined to comment.